PhD Studentship: Integrating AI to Quantify Pathogenic Alterations to the Blood-Brain-Barrier in a Human in Vitro Model
Manchester Metropolitan University
| Qualification Type: | PhD |
|---|---|
| Location: | Manchester |
| Funding for: | UK Students |
| Funding amount: | £19,237 for 2024/25 |
| Hours: | Full Time |
| Placed On: | 18th June 2024 |
|---|---|
| Closes: | 22nd July 2024 |
| Reference: | SciEng-TM-2024-Blood-Brain-Barrier |
Project summary
We are looking for a talented and motivated graduate in Biosciences, Biomedicine, Human Genetics or related discipline to engage in an exciting new project at Manchester Metropolitan University.
The project is focused on applying state-of-the-art tools and technologies to learn how inflammatory signals traverse the blood-brain-barrier and contribute to neurodegeneration in cerebrovascular disease. You will learn from our researchers how to apply human induced Pluripotent Stem Cells (iPSC) to convolute an in vitro chip-based complex cell model of the neurovascular unit (NVU). This NVU model will be the base to then utilise lentivirally transduced genetic reporters as quantitative readouts for neuronal and glial inflammation. You will then be instructed on applying AI/machine learning protocols to spatiotemporally quantitate these multi-fluorescence outputs in the NVU model with the aim of modelling extracellular vesicle-mediated inflammation.
The project will be supported by discipline-specific experts, and you will join a team of existing post-doctoral researchers and PhD students, with access to state-of-the-art facilities and an unrivalled environment to support our graduate students.
Specific requirements of the project
Graduate in Biosciences, Biomedicine, Human Genetics or related discipline.
How to apply
Interested applicants should contact Dr Tristan McKay for an informal discussion. To apply you will need to complete the online application form for a full-time PhD in Bioscience (or download the PGR application form). You should also complete a standard or Narrative CV demonstrating how the skills you have maps to the area of research and why you see this area as being of importance and interest.
If applying online, please upload your statement in the supporting documents section or email the application form and statement to mailto:PGRAdmissions@mmu.ac.uk. Closing date 22 July 2024. Expected start date October 2024.
Quote the reference: SciEng-TM-2024-Blood-Brain-Barrier
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