PhD Studentship: Analysis of the Influence of Selected Compounds on Biological Ageing

Project summary

This is a collaborative project between Manchester Metropolitan University and The University of Manchester Spin-Out company, Ravan Bio Ltd. Ravan Bio’s research has discovered new uses for existing approved drugs to inhibit the ageing process in mammals. The current project is to use a combination of molecular techniques, in vitro culture systems and studies in rodents to build on Ravan Bio’s findings, with the aim of refining dosimetry, regimen and the antiaging mode-of-action of the compounds under investigation.

It should be noted that, apart from providing medicated feed and the taking of non-invasive samples (e.g.  cheek swabs), no other experimental procedures will be carried out on animals other than to assess their lifespan and healthspan. Manchester Metropolitan University has new labs and investments in state-of the-art technologies that the student will benefit from as well as the chance to join a thriving postgraduate student culture.  

Aims and objectives

The project, using non-invasive samples from rodents, aims to understand the mechanisms of action for longevity drugs and to refine the dosimetry and regimen required to optimise these effects. Testing of epigenetic clocks, DNA damage, immune markers and cell experiments will all be used to address these questions.

Specific requirements of the project

The applicant should have experience in molecular and cellular biology and an honours degree at first or upper second class level in a relevant subject.

The candidate should have a first or upper second class (2:1) degree in an appropriate subject. Prior experience of cell culture and common molecular biology techniques such as DNA/RNA isolation, ELISA,  PCR, QPCR, Western blotting etc would be desirable although training will be given. No prior experience of handling laboratory animals is required as this will be optional. Good IT skills with Word, PowerPoint and Excel are essential and some knowledge of statistics is desirable.

How to apply

Interested applicants should contact Professor Chris Murgatroyd for an informal discussion. To apply you will need to complete the online application form for a full-time PhD in Life Sciences (or download the PGR application form). You should also complete a standard or Narrative CV demonstrating how the skills you have maps to the area of research and why you see this area as being of importance and interest.

If applying online, please upload your statement in the supporting documents section or email the application form and statement to mailto:PGRAdmissions@mmu.ac.uk. Closing date 22 July 2024. Expected start date October 2024.

Quote the reference: SciEng-CM-2024-Biological-Ageing

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