Location: | London |
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Salary: | £42,099 to £50,585 |
Hours: | Full Time |
Contract Type: | Permanent |
Placed On: | 17th June 2024 |
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Closes: | 12th July 2024 |
Job Ref: | B02-07105 |
About us
This is an exciting opportunity for a motivated and creative scientist to join the UCL Myeloma Laboratory in the Cancer Institute at UCL.
The UCL Myeloma Laboratory is the translational hub for national clinical trials in myeloma and SMM, and has a long tradition of working with patient samples, to address questions of disease biology, as well as to develop new treatments. The group is a multi-disciplinary team of cancer biologists, wet lab scientists and translational research clinicians.
About the role
Your project will focus on dissecting the tumour immune environment in the myeloma bone marrow, using high dimensional flow cytometry, single cell and bulk sequencing, and TCR sequencing.
Your project aims to determine the key changes in immune function that accompany malignant transformation, and that influence the response to therapy, using high dimensional flow cytometry, single cell and bulk sequencing, and TCR sequencing.
You will study tumour-directed responses in T cells, including the interactions with other immune cells such as myeloid and dendritic cells. You will become proficient in processing bone marrow and blood samples from patients entered into national trials in smouldering and newly diagnosed myeloma (COSMOS and RADAR).
You will work closely with other scientists in the Early Detection team, processing and preparing primary material for downstream analysis, including flow and mass cytometry, single cell and bulk sequencing. You will have opportunity to learn multi-spectral imaging and to apply deep learning, computer vision and spatial statistics to map the spatial distribution of immune cell subsets in the bone marrow.
You will work closely with Professor Yong, Dr Boyle, Dr Rees to design your experiments. You will be expected to drive and develop your project, taking responsibility for its progress. You will be encouraged to learn essential bioinformatics skills.
Applicants with limited experience of bioinformatics but sufficient familiarity with the experimental techniques and intense desire to expand their skillset in this area are encouraged to apply.
The post is funded for 2 years in the first instance, and is jointly funded by CRUK (Early Detection programme in Smouldering myeloma), and by Blood Cancer UK (Immune dysfunction in newly diagnosed myeloma).
About you
A background in immunology is essential. Experience in flow and mass cytometry, including the design of high-dimensional panels, functional immunology and relevant assays would be advantageous.
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