Research Associate - Muscle Dystrophies

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
We are looking for a basic scientist with experience in muscle diseases who is looking to progress in their career by joining a multidisciplinary team of researchers working on the mechanisms of disease of muscular dystrophies. You should already have experience in basic research in this field, including a clear understanding of the pathomechanisms of these diseases and up-to-date knowledge on the new therapies that are being developed. We are looking for someone with expertise in running different laboratory techniques, including cell culture, staining, WB, DNA and RNA analysis.

The role is to work on a new therapies and biomarker identification project for patients with muscular dystrophies. In this study we are going to apply cutting-edge technology to obtain new biomarkers that can be used to monitor disease progression in muscle dystrophies as well as characterize the biological and molecular features of fibro-adipogenic progenitor cells (FAPs) obtained from patients. We are going to test a battery of drugs with antifibrotic potential in cells derived from human skeletal muscles and in murine model of muscular dystrophy. Moreover, we are going to use cut-off technology to characterize the function of FAPs in the process of muscle degeneration including single cell RNA sequencing and 3D cell modelling.

This full-time post is offered on a fixed-term basis for a period of 18 months.

Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.

For informal enquiries contact: Prof Jordi Diaz Manera: Jordi.diaz-manera@newcastle.ac.uk.

Find out more about the JWMDRC here: https://jwmdrc.org.

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/.

Find out more about our Research Institutes here: https://www.ncl.ac.uk/medical-sciences/research/institutes/.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

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