Postdoctoral Fellow - Downward Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary

Julian Downward’s laboratory (Oncogene Biology) investigates the mechanisms by which mutant oncogenes drive the formation of tumours and how understanding this better can promote more effective approaches to treating cancer in the clinic. We particularly focus on the RAS family of oncogenes, which are the most frequently mutated oncogenic drivers in human cancer. The first drugs targeting the KRAS protein, sotorasib and adagrasib, have recently been approved for clinical use in lung cancer, but their effectiveness is limited due to the rapid development of drug resistance. We are interested in exploring the interplay between RAS oncogene signaling and the control of the tumour immune microenvironment (TiME) with the aim of improving therapies for RAS mutant tumours. We are seeking a talented and motivated postdoctoral research fellow with experience in tumour immunology to join our group.

Information about the work of the laboratory as a whole can be found at the links below:
http://crick.ac.uk/research/a-z-researchers/researchers-d-j/julian-downward/ 
http://scholar.google.co.uk/citations?user=9bDwgogAAAAJ&hl=en 
https://orcid.org/0000-0002-2331-4729

Key Experience and Competencies

Qualifications, experience and competencies

• PhD in relevant subject area or in the final stages of PhD submission
• Good knowledge and experience in cancer biology, molecular cell biology and immunology
• Technical expertise in tumour immunology, such as immune phenotyping by FACS, single cell sequencing, multiplexed spatial imaging or mass cytometry
• Experience in the use of mouse models in cancer or immunology research
• Experience in the use of bioinformatics to analyse large biological datasets
• Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
• Evidence of data presentation at scientific meetings
• Ability to work with minimal supervision using own initiative to organise and prioritise own work

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 31/07/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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