Postdoctoral Research Scientist (Signalling)

The Babraham Institute is a charity which is world renowned for its research in life sciences to enhance lives and improve wellbeing.

We are seeking a highly-motivated Postdoctoral Research Scientist, with an enthusiasm for proteostasis and ageing, to join The Samant Lab for a funded project exploring ubiquitin-mediated cellular proteostasis in the context of healthy ageing.

Detection and clearance of misfolded proteins is crucial for maintaining a balanced cellular proteome (‘proteostasis’)—a process that is compromised during ageing and ageing-related diseases. Successfully detected misfolded proteins are modified with a ubiquitin tag, which signals their degradation. Based on yet-to-be published work, we have discovered striking differences—conserved from yeast to human cells—in the ubiquitin modification of misfolded proteins with ageing and senescence. We now have a unique opportunity to explore how these differences impact proteostasis, with potentially profound consequences for our understanding of ageing and disease.

The successful applicant will join a dynamic lab that explores proteostasis across various models of health and disease, ranging from single-celled budding yeast to human cell culture and 3D organoid models.  The postdoc will be encouraged to drive their own research, combining the latest bespoke ubiquitin enrichment and detection tools with cutting-edge imaging, proteomics, and biochemistry. They will also collaborate with neighbouring labs as part of our co-ordinated effort to obtain an integrated view of proteostasis breakdown with age.

The Babraham Institute, with a long-standing commitment to improving lifelong health, has a renewed strategic focus on proteostasis. The postdoc will therefore have a chance to shape, from the outset, a growing, diverse, and vibrant community all geared towards addressing the same over-arching challenges. There will be a strong focus on career progression, with a support structure that includes internal and external mentors with experience across a range of academic and/or industrial sectors, tailored to the postdoc’s aspirations.

This is a fixed-term appointment with funding for this post expected to be available for a period of 2.5 years in the first instance, with the possibility of extension for a further 1.5 years.

Informal enquiries can be addressed to Rahul Samant (rahul.samant@babraham.ac.uk)

For more information on the work of the group, please visit: https://www.babraham.ac.uk/our-research/signalling/rahul-samant and https://samantlab.github.io/.

Applicants must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £33,500 per annum, if you have not yet been awarded your PhD.  All newly appointed postdocs will commence on the salary/scale point that reflects the number of years' post-PhD experience they hold on 30th June in the calendar year they commence employment.

Closing date for applications is Sunday 7^th July 2024. However, we reserve the right to close the vacancy early depending on the volume of applications received.

For further details about this position or to apply online please click on the 'Apply' buton above.

NO AGENCIES PLEASE

The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people.

The Babraham Institute abides by the principles of the government’s Disability Confident Scheme and has a positive approach to employing disabled people.

Advert information