PDRA in Physiology

Applicants are required to submit a current CV and cover letter.

Background and Context 

This project aims to develop a new sensing platform to resolve a long-standing puzzle: how extracellular Ca2+ coordinates pancreatic islet beta-cells for pulsatile insulin secretion. The latter is key to maintain the blood glucose homeostasis.  

Free ionic Ca2+ is now recognised as an indispensable messenger in mediating cellular activities in nearly every aspect of cellular life for almost all mammalian cells. Although the roles of intracellular Ca2+ in relation to different biological functions have been well characterised, insights into extracellular Ca2+ are constrained by the lack of appropriate sensing methodology capable of distinguishing the subtle changes of Ca2+ over the high basal level. To overcome this limit, this cross-disciplinary research will devote to developing a new analytical methodology in this regard.

This one-year full-time (negotiable for part time) post is funded by EPSRC International Collaboration Grants, 6 months at the University of Hull and the remaining time at University of Adelaide, Australia. Locally, the project will be conducted collaboratively with partner at Hull York Medical School; internationally, this project will be supported by partners based at the Adelaide Medical School. 

Throughout the time in Australia, the PDRA will be provided with allowance to cover the cost of airfares, accommodation, etc., equivalent to approximate a large surplus salary over the half-year time.

  Specific Duties and Responsibilities of the post 

The successful candidate will have a background in biosensing and bioimaging practice, and possess techniques in optical microscopy, optics-based microchips sensor, physiological measurement, in addition to the general biomedical knowledge and skills. 

For an informal conversation about the position please contact - Jiangbo.zhao@hull.ac.uk

Further details:

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