Research Assistant/Fellow

About us

The Centre for Amyloidosis maintains a longstanding high profile clinical and basic science research programme and serves as the national referral centre for patients with amyloidosis and inherited periodic fever (auto-inflammatory) syndromes. http://www.ucl.ac.uk/medicine/amyloidosis. The post holder will play a key role in a priority research project to understand the immune response, isolate and characterise antibodies from patients with systemic amyloidosis, funded by a commercial partner.

About the role

To assist the existing investigators by performing laboratory-based research to understand the immune response, and to isolate and characterise antibodies from patients with systemic amyloidosis. Experimental techniques will include multiparameter flow cytometry for phenotypic characterisation and isolation of memory B-cells, population and single cell BCR sequencing and cloning, recombinant protein production, antibo dy purification, and assays of antibody binding characteristics, including ELISA and in vitro cell culture assays. Duties and responsibilities Include the following: Perform experiments; maintain an accurate lab book and file their data in a form accessible to other members of the lab; maintain and update laboratory standard operating procedures and risk assessments as required; maintain accurate and up-to-date liquid nitrogen/freezer storage and database recording for samples; order and maintain lab stocks, effective running of laboratory equipment, trouble-shooting problems where necessary; carry out any other duties as are within the scope, spirit and purpose of the job as requested by the PIs.As duties and responsibilities change and develop the job description will be reviewed and be subject to amendment in consultation with the post holder.

About you

Key requirements include BSc, MSc and/or PhD for appointment at Grade 7 in Biology / Immunology / Biomedical Sc iences or related subject General laboratory skills Experience of working in a research laboratory Experience in human cellular immunology Good level of competency at mammalian cell culture Good level of competency at multiparameter flow cytometry Experience of molecular biology (PCR/DNA purification, cloning) Evidence of outstanding attention to detail and a methodical approach Accurate and complete record keeping and ability to manage time and work to strict deadlines.

What we offer

This is an exciting opportunity to join a multidisciplinary team working across the Division of Medicine. As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: • 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) • Additional 5 days’ annual leave purchase scheme • Defined benefit career average revalued earnings pension scheme (CARE) • Cycle to work scheme and season ticket loan • Immigration loan • Relocation scheme for certain posts • On-Site nursery • On-site gym • Enhanced maternity, paternity and adoption pay • Employee assistance programme: Staff Support Service • Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we knowdiversity fosters creativity and innovation, and we want our community torepresent the diversity of the world’s talent. We are committed to equality ofopportunity, to being fair and inclusive, and to being a place where we allbelong. We therefore particularly encourageapplications from candidates who are likely to be underrepresented in UCL’sworkforce. These include people from Black, Asian andethnic minority backgrounds; disabled people; LGBTQI+ people Our department holds an Athena SWAN Silveraward, in recognition of our commitment and demonstrable impact in advancinggender equality.

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