PhD Studentship: Nanotechnology for Biosensor Diagnostics

Primary supervisor - Dr Maria J. Marin

Biosensors have long been used in scientific research and biomedical diagnosis, but with the advent of wearable glucose-monitoring medical devices, they are becoming more prevalent in personalized healthcare. The use of biosensors is attracting increased attention, driven by technological advancements and improved nanotechnologies. However, applications continue to be limited by the chemical functionalisation used within the biosensor and the sensitivity of the detection system. 

This project aims to enhance understanding of how surface chemistry, valency, and functionalisation impact biosensor sensitivity by exploring gold nanoparticle and graphene-based sensors. Biosensors typically involve a bio-receptor (small molecule ligand/antibody/nucleic acid aptamer) attached to a transducer (often a semi-conducting nanomaterial). The assembly strategy directly affects detection capability, sensitivity and selectivity. 

Leveraging our expertise in multi-functional nanoparticle-based sensors, biomolecule-based detection and electrochemical based technologies, we aim to develop affordable, high-performance sensing techniques for biomedical applications. A key focus will be on Graphene Field-Effect Transistor (GFET) molecular sensors known for their rapid detection capability, ease of use, low fabrication costs, and superior sensitivity compared to traditional methods.

We propose a multi-faceted approach to build nanoplatforms with multiple functionalities, benchmarking novel graphene-based technologies against existing nanoparticle-based detection, and allowing comparison of 2D and 3D presentation chemistries.

This PhD studentship is ideal for candidates with a strong understanding of chemical or physical sciences and interest in an interdisciplinary project at the chemistry-biology-engineering interface. The selected PhD candidate will be trained in the synthesis and characterisation of nanomaterials alongside the development of innovative analytical techniques and diagnostic devices. The student will have access to state-of-the-art facilities across the Norwich Research Park and will be equipped with relevant transferrable skills by the end of their PhD. 

Entry requirements: 2:1 and Masters in Chemistry, Biochemistry, Natural Sciences, Chemical Engineering.

Mode of study: Full-time

Start date: 1 October 2025

Funding Details

Additional Funding Information

This PhD studentship is funded for three years by the Faculty of Science, and is available to UK/Home applicants. Funding comprises an annual stipend (currently £19,237 pa for 2024/25), Home tuition fees and research costs.

Advert information