Research Fellow in Regulatory Genomics

Salary: Full time starting salary is normally in the range £36,130 to £45,413 with potential progression once in post to £48,149

Contract Type: Fixed Term contract up to April 2028 

Background

To create and contribute to the creation of knowledge by undertaking a specified range of activities within an established research programme and/or specific research project.

This Wellcome Trust-funded post is established to study the mechanisms of transcription start site (TSS) selection and TSS-mediated mRNA diversification in tumours. The post holder will be part of a multi-disciplinary research team within the Department of Cancer and Genomic Sciences. The main role will be to apply and develop new methods of genome wide analysis of transcription initiation dynamics on the single cell level in the complexity of tumor organoids and in the developing vertebrate embryo and will use genomics technologies (CAGE-seq, single cell ATAC seq, single cell 5’ end transcriptomics etc.) and then analyse the data by cutting edge computational genomics tools to achieve new models of transcription regulation during cancer development and morphogenesis and to answer questions about transcription start site regulation in diverse cell populations responding to developmental and /or growth signals. They will perform and develop assays for single cell genomics and develop and apply genomics data analysis tools and will have the opportunity for advanced training in these areas.

Role Summary

• Work within specified research grants and projects and contribute to writing bids 
• Operate within area of specialism
• Analyse and interpret research findings and results 
• Contribute to generating funding 
• Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar

Main Duties

The responsibilities may include some but not all of the responsibilities outlined below.

• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Analyse and interpret data
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication, research seminars etc

Person Specification

• First degree in biology or related subject and normally, a PhD relevant in biomedical research area or equivalent qualifications
• High level analytical capability
• Ability to communicate complex information clearly
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones including: organoid culture (preferably cancer organoids), single cell genomics data generation, single cell transcriptomics data analysis 
• Experience with transcription start site detection and analysis (e.g. CAGE-seq data analysis)
• Ability to work with complex in vivo models (e.g. organoids or zebrafish embryos)
• Ability to assess resource requirements and use resources effectively 
• Evidence of researcher capabilities in the form of peer reviewed publication(s)
• Understanding of and ability to contribute to broader management/administration processes
• Those with protected characteristics are treated equally and fairly

Informal enquiries to Ferenc Mueller, email: f.mueller@bham.ac.uk 

To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.

Valuing excellence, sustaining investment
We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working.

Closes: 3^rd April 2025

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