Senior Scientific Associate (Fixed Term)

Join us at the world-leading Cancer Research UK Cambridge Institute, a unique department of the University of Cambridge, where we’re eagerly searching for our new Senior Scientific Associate to join the Crossley Group!

About the Role

The Crossley lab (https://www.cruk.cam.ac.uk/research-groups/crossley-group/) studies RNA-DNA hybrid molecules called R-loops - how they become pathological, impact genome stability and innate immunity, as well as how these molecules themselves or cellular responses to them may be harnessed for cancer detection and treatment.

Typical techniques used in the lab are molecular biology (cloning, western blotting, human cell culture, CRISPR/Cas, lentiviral infection, qPCR), RNA/nucleic acid biochemistry (RNA/DNA and RNA-DNA hybrid isolation, immunoprecipitations, pull-downs), immunofluorescence microscopy/flow cytometry and genomics (NGS library preparation, bioinformatics). We are particularly looking for individuals with strong molecular biology and biochemistry skills, and previous experience with mammalian cell/tissue culture. In-depth expertise in at least one of the following is required: genome stability, RNA biology, chromatin biology, innate immunity or cancer biology. Experience in next generation sequencing and/or bioinformatics will be advantageous (but not essential).

We seek an experienced, organised and collaborative individual for this role, which will mainly involve experimental research, with time also spent on scientific support and (ideally) lab management. You will have the unique opportunity to take on a leadership role in a new lab, assisting Dr. Crossley in managing projects in the lab, developing new scientific directions, and providing technical assistance and guidance to PhD students, postdocs and research assistants.

We are interested in individuals who are flexible in leading independent projects, as well as working collaboratively within and outside of the group, and helping others when needed. You should be enthusiastic about setting up a positive lab culture, including effective teamwork, communication and organised systems (for data/code/reagents/record keeping). You should be detail-oriented and have a positive, can-do attitude to problem-solving. Additionally, you should also have a PhD degree in a relevant field.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy and to view further information about the role, please click on the apply button above.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW45419 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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