Research Associate (Fixed Term)

We invite applications for a Postdoctoral Research Associate to join the research group of Dr. Antoine Hocher in the Department of Genetics, based in central Cambridge.

Our lab explores molecular mimicry and chromatin evolution. We combine molecular biology, phylogenetics, proteomics and genetics.

This postdoctoral position focuses on studying and engineering proteins that mimic DNA. Molecular mimicry is a powerful evolutionary strategy observed across diverse organisms, from insects to vertebrates. While striking examples of phenotypic mimicry are well-documented, systematic approaches to identify and manipulate molecular mimicry remain largely unexplored.

The successful candidate will lead wet-lab projects aimed at:

• Developing high-throughput environmental DNA screens to uncover new cases of molecular mimicry.
• Engineering DNA-mimicking proteins using directed evolution platforms.
• Dissecting the mechanisms of action of newly identified DNA mimics.

By applying cutting-edge approaches, this work aims to systematically uncover DNA mimics and their targets, with potential applications in inhibiting DNA-binding proteins and advancing our understanding of molecular mimicry as a biological phenomenon.

This position provides a unique opportunity to develop expertise in diverse high-throughput techniques (proteomics, transcriptomics, directed evolution). The successful candidate will benefit from the lab's combined expertise in wet-lab molecular biology and computational biology.

Prior experience in microbiology, protein biology or experimental evolution is advantageous. Computational biology expertise is not required. A curious, persevering, and independent mindset is essential.

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy and to view further information about the role, please click the 'Apply' button above. 

For informal enquiries about the role please contact Dr Antoine Hocher ah2368@cam.ac.uk

Please quote reference PC45382 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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