Postdoctoral Research Associate: Neurophysiologist

We are seeking a neuroscientist with a strong background in visual and/or circadian biology to work as part of the Sleep and Circadian Neuroscience Institute (SCNi) within the Nuffield Department of Clinical Neurosciences (NDCN). The research interests of the SCNi are to: (A) Understand the neural mechanisms that generate and regulate sleep and circadian biology (B) Define the mechanistic links between sleep/circadian rhythm disruption and disorders of the central nervous system and © Apply this knowledge for the development of evidence-based clinical interventions.

 

The successful candidate will be responsible for leading a specific research project entitled ‘Investigating the multiple roles of cryptochromes in animal magnetoreception’ which will be based within the SCNi. They will work closely with Prof Stuart Peirson ( https://www.ndcn.ox.ac.uk/team/stuart-peirson) and Mark Hankins ( https://www.ndcn.ox.ac.uk/team/mark-hankins).  This project is part of a Wellcome Discovery Award, in collaboration with the University of Leicester (Profs Ezio Rosato, Bambos Kyriacou), Manchester (Prof Richard Baines) and the National Physics Laboratory (Dr Alex Jones).

 

Many species, including humans, are reported to be magnetosensitive. Indeed, some animals navigate using the weak magnetic field (MF) of Earth. Others do not, but there are accounts of MF effects and the concern that exposure to low frequency MFs may affect health. Whether the same or different mechanisms may be involved, is currently unknown.

 

One mechanism has acquired experimental prominence. Cryptochromes (CRYs), best known for their role in circadian rhythmicity, may mediate magnetosensitivity via a photochemical quantum reaction involving CRY-bound flavin adenine dinucleotide (FAD) and a chain of tryptophan residues within CRY that generate a radical pair (RP). Unexpectedly, we have demonstrated that the CRY C-terminal (CRY-CT), without the canonical FAD binding site or tryptophan chain, elicits behavioural and cellular responses to MFs in Drosophila melanogaster. Our results do not necessarily contradict the RP model but urge a fundamental revision of its canonical interpretation. We propose a multidisciplinary programme of work examining each level of the sensory chain, including detection, signal transduction and amplification, cellular and behavioural responses. Our combined expertise includes quantum physics, computational chemistry, protein biophysics, electrophysiology, molecular genetics, and behaviour. We are thus uniquely positioned to address and move towards solving this fascinating and fundamental biological question.

 

Laboratory work will involve the use of electrophysiological, transgenic and behavioural techniques including multielectrode array electrophysiology, activity monitoring and behavioural testing. Experience in the analysis of complex datasets is essential. The candidate must have or be close to completing a Phd/DPhil. A Home Office Licence (A-C) or equivalent experience would be an advantage. The post holder will be expected to contribute to the training and mentoring of some junior staff.

 

 

 

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