Research Associate in Bioinformatics

Company description:

University of Sheffield

Job description:

With only ~10% of Amyotrophic lateral sclerosis (ALS) patients possessing an identified genetic driver, there is a substantial missing heritability which cannot be explained by known ALS genes. In the Cooper-Knock lab, we combine cutting-edge machine learning, with functional genomics techniques including spatial transcriptomics and single-cell sequencing, to power the search for cell-specific genetic drivers of ALS

We are looking for a highly motivated and enthusiastic postdoctoral candidate to work with 10x Genomics Xenium spatial transcriptomics profiling of ALS patient tissue to define, at a molecular level, cellular interactions that drive risk and severity of ALS. The data is in place at time of writing. They will be based in the Dr Johnathan Cooper-Knock lab at the Sheffield Institute for Neuroscience (SITraN), an award-winning centre for excellence for the study of neurodegenerative diseases and drug-discovery. We are particularly keen to support researchers with career development in line with the research development concordat and will actively support those keen on applying for career development fellowships. Candidates are strongly encouraged to contact Johnathan (j.cooper-knock@sheffield.ac.uk) to discuss the project prior to application.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

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