Research Assistant/Associate-Structural & Chemical Biology to Generate Hypotheses for Drug Discovery

Company description:

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

Salary:

Research Assistant: £32,546 to £34,132  per annum

Research Associate: £35,116 to £40,497 per annum

Job description:

The Role

You will be part of a team based in the Newcastle Cancer Centre that will use structural, chemical and cell biological tools to understand the roles and mechanisms of CDKs to generate hypotheses for drug discovery. You will use contemporary structural, biochemical, and biophysical techniques to characterise CDK complexes involved in the control of the eukaryotic cell cycle and the regulation of transcription. You will be an accomplished researcher with experience in inter-disciplinary protein structure determination and expertise in contemporary structural biology techniques, with a requirement for familiarity with cryo electron microscopy and X-ray crystallography.

You will design, implement and deliver novel strategies to prepare protein complexes. You will have experience in contemporary techniques in high throughput protein crystallography for inhibitor design. You will also have experience in using biophysical techniques to characterise protein structure, function and regulation. You will work within a large multi-disciplinary team that includes biologists, structural biologists and chemists.

The position is funded by the Medical Research Council and a fixed term post until 30th September 2026.

Please provide evidence of how you meet the essential criteria required for the role outlined in ‘The Person' by uploading a letter of application along with your Curriculum Vitae (CV).

Informal approaches can be made to Professor Jane Endicott (jane.endicott@ncl.ac.uk) or Professor Martin Noble (martin.noble@ncl.ac.uk)

Information about the Cell Cycle Structural Biology Group can be found at: https://research.ncl.ac.uk/cellcyclestructuralbiology/

Information about the Faculty of Medical Sciences is available at: https://www.ncl.ac.uk/medicalsciences/

We are committed to the professional career development of all our colleagues. You will benefit from a range of excellent development opportunities including internal and external training. As part of this commitment to research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

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