Research Associate (Phosphoinositide Signalling in Colorectal Cancer Metastasis)

We are seeking to appoint an experienced Research Associate to work with the laboratories of Professor David Bryant and Professor Owen Sansom on the role of phosphoinositide signalling in colorectal cancer metastasis.

The aim of this project is to investigate the mechanisms of metastasis emerging from a cutting-edge in vivo CRISPR screens of tumourigenesis and metastasis using transplantable organoid models of colorectal cancer.

The Bryant Lab focuses on how cell and tissue polarity is controlled in the context of health and disease. We utilise 3-dimensional organoid culture coupled to state-of-the-art live-cell and high-throughput imaging, cell biology, biochemical and computational approaches to understand how tissue organisation is controlled. In this UKRI-funded collaboration with Owen Sansom’s lab, you will utilise organoids derived from mouse models of metastatic colorectal cancer to understand how phosphoinositides contribute to metastasis.

The Bryant and Sansom labs are situated at The Cancer Research UK Scotland Institute as part of the University of Glasgow - one of Europe's leading cancer research centres. It is core funded by Cancer Research UK and supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on mouse models, imaging and tissue organisation.

The successful, highly motivated candidate is expected to follow-up on an innovative, cutting-edge in vivo CRISPR screening of transplantable organoid models of metastasis, as part of a team of researchers dedicated to this aim. In addition, the candidate is expected to lead more junior members of the laboratory in transplantable models of metastasis.

The successful candidate will also be expected to contribute as part of a multi-researcher team to the formulation and submission of research publications as well as help manage and direct this complex and challenging project as opportunities arise.

www.crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research-groups/dave-bryant-epithelial-polarity.html

www.crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research-groups/owen-sansom-colorectal-cancer-and-wnt-signalling.html

Informal enquiries should be directed to Professor David Bryant, David.Bryant@glasgow.ac.uk

This post is full-time and has funding for up to 24 months.

To apply online at: www.jobs.gla.ac.uk/job/research-associate-phosphoinositide-signalling-in-colorectal-cancer-metastasis?source=gla.ac.uk

We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community www.gla.ac.uk/myglasgow/humanresources/equalitydiversity.

We endorse the principles of Athena Swan www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan and hold bronze, silver and gold awards across the University.

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