Postdoctoral Research Fellow

Our recent work established that a topoisomerase causes genome damage at ribonucleotides embedded within DNA in cancer (Reijns et al, Nature 2022). Furthermore, this endogenous damage occurs frequently in normal tissues, with an associated mutational signature detected in ageing brains.   

This postdoctoral position is to investigate how and where this genome instability arises in replicating and non-replicating cells, to gain insight into its involvement in cancer and other human diseases. It is also likely to shed light on how DNA damage drives innate immune-mediated inflammation in Aicardi-Goutières syndrome.   

The post-holder will be part of a multidisciplinary team in the lab of Prof. Andrew Jackson, working in a cross-disciplinary environment that addresses both fundamental cellular processes and disease mechanisms. The lab is embedded in the Institute of Genetics and Cancer, a highly collaborative and supportive environment.  

The research group is internationally diverse and strongly competitive consistently publishing in high-level journals including 5 papers published in Science and Nature in the last 10 years.

This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. We are also open to considering requests for hybrid working (on a non-contractual basis) that combines a mix of remote and regular on-campus working. 

The salary for this post is £40,247 to £47,874 per annum. 

Advert information