Research Fellow

About us

The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. Th e Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

We are seeking a highly motivated and skilled research fellow to join the Dubowitz Neuromuscular Centre (DNC) to work on this exciting and promising project funded by Action Medical Research and LifeArc aiming in improving the effectiveness of treatments for Duchenne Muscular Dystrophy by combining therapies, specifically histone deacetylase inhibitors (HDAC1) with antisense oligonucleotides (AONs). The study will investigate whether coadministration of HDACi with AONs in DMD patients’ cells increases the amount of dystrophin protein produced. Increasing DMD protein production will ameliorate DMD and by using only previously developed drugs, positive findin gs from this project will be rapidly translated into the clinic.

About you

Applicants must have PhD in Child Health or a relevant subject area, prior experience in cellular culturing, RNA and protein isolation from cells, in molecular biology techniques including quantitative RT-PCR; protein isolation and analysis by gel or capillary protein electrophoresis, and western blot analysis. Excellent organizational, writing and record-keeping skills are essential. Applicant should be an enthusiastic person, prone to team works but able to independently run experiments. Attention to detail and problem-solving approach are desirable.

What we offer

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s t alent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma.

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