PhD Studentship: Mechanically Interlocked Ligands for Medical Imaging

Background – metal coordination and the mechanical bond Interlocked molecules made using metal-templated approaches are mechanically chelating ligands for transition metal ions. However, this feature of rotaxanes and catenanes has not been widely exploited, despite early results suggesting that encapsulating metal ions in this way leads to exciting properties. More recently, we have demonstrated that the mechanical bond can stabilise normally unstable organometallic complexes and provide access to unusual coordination environments that cannot be produced in other ways. This can in turn lead to unusual magnetic properties.

The project

The successful candidate will join a vibrant, diverse group of researchers to develop mechanically chelating ligands for application in medical imaging (MRI and SPECT). To achieve this, they will make use of the Goldup Group’s efficient methods for the synthesis of rotaxanes and catenanes (e.g.:7,8) and collaborate with leaders in these imaging techniques at the University of Birmingham and the University of Zurich.

Training and mentoring 

The successful candidate will receive training in advanced synthetic organic chemistry techniques, catalysis and supramolecular chemistry and other specialist areas as required by their project. They will gain extensive experience of a range of analytical techniques including advanced NMR, single crystal x-ray diffraction and HPLC analysis. Interested candidates will also have the opportunity to gain experience of computational modelling. They will be mentored by Professor Goldup to improve their scientific writing, presentation skills and ability to design and execute new scientific projects. 

Completing a PhD in the Goldup Group will prepare students for leadership roles in scientific research, as well as positions across the scientific sector more generally. The Goldup Group Research in the Goldup Group (https://golduplab.org/) at the University of Birmingham focusses on the synthesis, properties and applications of mechanically interlocked molecules such as rotaxanes and catenanes. This work takes place at the interface of organic synthetic and supramolecular chemistry and requires collaborations with a range of other disciplines from materials science to chemical biology.

Application process

Candidates should normally have, or expect to receive, a first or upper second (2.1) class Masters degree (or equivalent). Interested candidates should contact Professor Goldup (s.m.goldup@bham.ac.uk) by email in the first instance with a copy of their CV and a covering letter outlining their research interests.

The School of Chemistry is keen to achieve a gender and diversity balance across the School and welcome applicants from all backgrounds. The School holds an Athena SWAN Bronze Award, which recognises its work in promoting women’s careers in science, technology, engineering, mathematics and medicine (STEM) in higher education.

Funding Details

Additional Funding Information

This 3.5 year studentship includes a tax-free stipend and tuition fees at the standard UKRI rate (stipend was £19,237 academic year 2024-2025). We offer a fully-funded programme of integrated research and skills training. Support for conference attendance and research materials will be available. Please note that, due to funding restrictions, applicants not eligible for UK home fee status will only be considered in exceptional circumstances.

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