Postdoctoral Research Assistant - Protein Crystallography fragment-based lead discovery (AMR)

We are seeking to appoint a Postdoctoral Research Assistant for the Oxford university-based Protein Crystallography Small Research Facility (PX-SRF) under the supervision Dr Lizbé Koekemoer and Dr Jani Bolla (Department of Biology). This project is funded by the Ineos Oxford Institute for antimicrobial research (IOI) and is a collaboration between the Centre for Medicines Discovery (CMD), the Department of Biology, Pharmacology, the Sir William Dunn School of Pathology, and the IOI, all based at the University of Oxford.

 

You will primarily be characterising a transcriptional regulator from Neisseria gonorrhoeae Mtr, Your role is to execute and drive crystallography projects including the production of the correct protein for crystallization, optimizing crystal systems for fragment screening, crystallographic fragment screening (XChem), data analysis and supporting follow-up compound design and analysis of protein ligand complexes. Experience in crystallography and protein-ligand complexes is essential, with knowledge of crystallographic fragment screening and structure-based small molecule discovery highly desirable.

 

This is a unique opportunity to be part of a large inter-disciplinary project team and to collaborate with a diverse set of scientists across the university, specifically the Bolla group at Biology and the Lanyon-Hogg group at Pharmacology, in an academic setting both on scientific outputs and the development of new methodologies, algorithms and tools for data analysis and dissemination. As part of IOI you will interact with various scientist to transfer protocols, help develop research questions, to present results and plan follow-up experiments.

 

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

 

This position is offered full time on a fixed term contract for 2 years.

 

Only applications received before 12 midday on Monday 13 January 2025 will be considered. Interview are planned to take place on the week commencing 20 January 2025.

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