Postdoctoral Research Assistant in R-Loop Biology

Location: Sir William Dunn School of Pathology, South Parks Road, Oxford

We are seeking to appoint a well-trained, enthusiastic and self-motivated scientist to join the laboratory of Associate Professor Natalia Gromak at the Sir William Dunn School of Pathology, University of Oxford. The main interest of the laboratory is to investigate the mechanisms underlying the function of non-canonical RNA/DNA structures (R-loops) in health and diseases. 

The post-holder will be responsible for managing their own academic research. You will establish and optimise protocols, design and accurately execute experiments and contribute conceptually to the overall research programme. The post-holder will contribute directly to scientific discussions with the Group Leader and other members of the group and collaborators on the project. You will also supervise and train junior staff in molecular biology/biochemistry. 

The post holder should hold, or be close to completion of, a PhD/DPhil in biochemistry, molecular/cell biology or genetics and have a good understanding of the principals of gene expression in higher eukaryotes. The research project will involve a wide range of molecular biology and biochemical techniques, including RNA work, protein purification, mammalian cell culture, next generation sequencing genome-wide analyses (ChIP) and mass spectrometry. Previous expertise in either molecular mechanisms of transcription, RNA processing, DNA damage or R-loop biology would be essential for this job. You should also have strong publication record, good organizational and communication skills, and being able to work as part of a team. Candidates with experience in genomic analyses, proteomic approaches, imaging analysis, iPS differentiation and bioinformatics would be especially welcome. 

Further information about the group and project can be found on: https://www.path.ox.ac.uk/content/natalia-gromak. 

The post available as a fixed-term contract for 2 years in the first instance. If you are interested in this position, and have the skills and experience we are looking for, please apply below. You will be required to upload a CV and supporting statement as part of your online application. 

The closing date for applications is midday on Monday 20 January 2025. Interviews will be held as soon as possible thereafter.

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