Senior Bioinformatician (Genomics)

Short summary

An exciting Senior Bioinformatician post is available in the Cancer Dynamics Laboratory. The post holder would work across multiple on-going projects of the lab, including a dedicated role within the MANIFEST project (“Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity”), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multiomic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care comprising major NHS trusts, academic institutes and universities, and industry partners.

The successful candidate will join the bioinformatics team at the Cancer Dynamics Laboratory. This role will involve leveraging data from the MANIFEST, TRACERx Renal (http://tracerx.co.uk/studies/renal/), and PEACE (https://clinicaltrials.gov/study/NCT03004755, renal cancer and melanoma) studies. The primary responsibility of the post-holder will be to perform bioinformatics discovery analyses aimed at identifying genomic and transcriptomic features that influence responses and resistance to immunotherapy.

Key Responsibilities

These include but are not limited to:

• To work within the bioinformatics team of the Cancer Dynamics lab, and collaborating with other groups at the Institute, academic, clinical and industry partners of MANIFEST.
• To conduct analyses of genomic and transcriptomic data, using established pipelines.
• To analyse DNA sequencing data, identifying somatic mutations, copy number aberrations, and neoantigens.
• To analyse RNA sequencing data, performing immune deconvolution and identifying gene expression signatures.
• To evaluate and provide state-of-the-art tools, databases, protocols and methods necessary for the analysis of above-mentioned biological data.
• To liaise and coordinate between the project collaborators which include clinicians, cancer biologists, machine learning experts and mathematical modellers.
• To document all analyses in an accurate, timely and clearly presented manner, and use this to prepare data summaries and reports as and when required.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the ‘Apply’ button above.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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