Senior Research Associate (Fixed Term)

We are seeking an experienced and motivated researcher to work on one of the first projects contributing to the Cambridge-GSK Translational Immunology Collaboration (CG-TIC). CG-TIC is a new translational immunology initiative between Cambridge and GSK focused on renal and respiratory diseases. It will leverage the world-class capabilities of Cambridge and GSK, targeting diseases of high unmet medical need, with the aim of delivering impact to patients while advancing the GSK pipeline, and supporting research in Cambridge. The partnership is built around three key themes, involving the integration of patient phenotyping, understanding mechanisms of disease, and advancing oligonucleotide therapeutics.

The successful applicant will be part of the renal Mechanisms of Disease theme and will join the research group of Professor James Nathan, based in the Cambridge Institute of Therapeutic Immunology and Infectious Disease on the Cambridge Biomedical Campus. You will also be part of the CG-TIC and will join a growing band of researchers supporting this collaboration. The work will involve gaining a better understanding of the role of the type 1 interferon pathway in kidney disease, using unbiased screening approaches to uncover novel regulatory pathways in innate immunity.

The ideal candidate will have experience of CRISPR-Cas9 techniques and running CRISPR screens to uncover novel regulators of key pathways in innate immunity using flow cytometric approaches. The ability to develop techniques to assess the extent of post translational modification of key immune signaling proteins is also essential. A willingness to contribute to a large-scale collaboration with an industry partner, including learning new ways of working, will be key to the role.

Informal enquiries regarding this position are strongly encouraged: contact Dr Nicholas Horrocks (nh415@cam.ac.uk), Scientific Research Project Manager, CITIID, or Prof. James Nathan (jan33@cam.ac.uk).

Fixed-term: The funds for this post are available until 1 October 2026 in the first instance.

To apply online for this vacancy and to view further information about the role, please click on the apply button above.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 19th December 2024

The interview date for the role is: To be confirmed

Please quote reference RC44327 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Advert information