Postdoctoral Fellow – Cader Lab

Short summary

The Cader lab studies the complex interplay between metabolism and immunity across every level of organismal organisation from proteins to cells to organs and the whole-body. In doing so, we wish to learn how our diet, microbiota, and other environmental factors shape our immune system in health and disease.

The Project

There are a number of exciting lines of investigation, which would be available for the successful applicant(s) to pursue. In particular, the prospective candidate(s) would drive either of the following projects:

• During the course of their activation, immune cells require distinct metabolic states necessary for the different phases of an immune response. Our work has highlighted that these are crucial for supporting the energetic and chemical demands of immune signalling, which must respond rapidly but flexibly to changing levels of intracellular pathogenic threat.
• Metabolic coordination is even more poorly understood at a whole tissue or organ level. In this project, we seek to investigate cellular metabolism in vivo and study metabolic cross-talk in physiological and disease relevant states in animal models. The successful candidate will utilise orthogonal methods for tracking and functionally investigating immunometabolic processes in vivo

Both post-doctoral projects will harness genetic and chemical tools to manipulate and image key metabolic and redox pathways. Candidates will also be encouraged and supported to innovate new tools and methods for studying immunometabolism both in vivo and in cells through genetic engineering and chemical biology approaches.

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 5/01/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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