PhD Studentship: SubCortical Maternal Complex - A Small Complex With A Big Role In Early Human Development

Primary supervisor - Prof David Monk

Human fertility is declining, which is observed via the use of IVF and an increase in overall miscarriage rates. Our team aims to understand the molecular mechanisms involved in mammalian fertility and early post-fertilization development. We have identified the SubCortical Maternal Complex (SCMC) as a key component involved in the oocyte maturation and pre-implantation development, genetic variants of which have recently been associated with embryonic epigenetic deregulation and embryo demise. Despite these links to female fertility, the precise confirmation of the SCMC and the impact of genetic variants remain poorly investigated. 

This project aims to use state-of-the-art biophysical techniques to determined SCMC structure and determine the influence of genetic variants on complex integrity and stability. 

The ideal candidate will possess a minimum of an Upper Second-Class Honours degree in a biology-related topic or have equivalent experience in molecular biology, but most importantly they must have a passion for biomedical research. Given the interdisciplinary nature of the project, we are looking for a candidate enthusiastic to learn different molecular and biophysical techniques, as well as computational skills.

The project is a joint venture between the groups of Professor David Monk, Dr Andrew Gates at the University of East Anglia (UEA) and Dr Abbas Maqbool at the John Innes Centre. In addition to the generic skills training that is provided through the UEA PGR training programme, the student will be supported by the excellent Structural and Biophysics departments at JIC & UEA. They will join a vibrant research team at the interface between genetics, basic and translational research. 

All candidates are strongly advised to contact the PI (d.monk@uea.ac.uk) to discuss the project prior to formal application.

Entry requirements

The standard minimum entry requirement is 2:1 in Biomedical Sciences, Genetics, Biochemistry.

Start date: 1 October 2025

Funding Details

Additional Funding Information

This PhD project is in a competition for a Faculty of Science funded studentship. Funding is available to UK applicants and comprises ‘home’ tuition fees and an annual stipend of £19,237 (for a maximum 3 years). 

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