Senior Laboratory Research Scientist - Human Models

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Human Models Core (HMC) is an integral part of the Human Biology Facility. HMC comprises of scientific and technical staff from the Francis Crick Institute who provide a service and support to all researchers. With close links to the Human Biology Governance Team and external partners the HMC provide a comprehensive range of services and support for human model’s research. Within the HMC there are 4 distinct core units: viral vectors, human embryo and stem cell unit (HESCU), human cell engineering and primary models.

Project summary

HESCU is involved in developing key models for human disease by reprogramming somatic cells into PSC lines and assist with downstream applications like gene editing or differentiation.

HESCU provides and maintains a well-equipped laboratory space and as a communal lab space, facilitates interaction between the groups working with human models, pluripotent stem cells and gene editing. The Lab aims at fostering collaborations, knowledge hub and the sharing of protocols between the scientific groups who use the facility. We currently work with users to provide support and promote best practice, in the areas of growing pluripotent stem cells, differentiation, characterisation, banking and method development.

Key Responsibilities

• Reprogramming somatic cells to iPSCs.
• Generation of iPSC derived organoids and other models
• Working and collaborating with scientist to develop scientific projects
• Provision of pluripotent stem cell culture suite, PSC QC and technical support to scientific groups within the Francis Crick Institute.
• Teaching and training scientists in the best practice skillsets necessary to grow, characterise, differentiate and bank human PSC.
• Support PSC genome editing unit, where needed
• Provision of support for the day-to-day running of the facility including but not limited to housekeeping, equipment maintenance.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

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