Principal Laboratory Research Scientist

We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function.

We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng. et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration.

This is an excellent opportunity for a highly motivated senior scientist to be heavily involved in the start-up of a major laboratory and to provide senior level support in broad scientific management for the research group. Alongside providing technical assistance to other lab members, there will be opportunities and strong encouragement to lead independent projects in areas such in vivo gene editing and liver epigenetics.

Key Responsibilities

• Independently devising and leading projects within the TRCE research program
• Establishing new methodologies in the lab
• Maintaining laboratory organisation and supplies
• Supporting the Group Leader in day-to-day operations
• Deputising for when the Group Leader is unavailable
• Training and supporting lab members in standard operating procedures
• Facilitating collaborations within and outside the Crick
• Provision of technical and research support in the area of human stem cell biology including the tissue culture of pluripotent stem cells and organoids
• Human cell engineering encompassing molecular biology and CRISPR/Cas gene editing
• Management of regulatory protocols and research governance for the lab

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the 'Apply' button.
• The closing date for applications is 02/01/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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