Laboratory Research Scientist - MANIFEST Research Platform / Human Biology Facility

Short summary

An exciting Laboratory Research Scientist post is available for MANIFEST (“Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity”), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multi-omic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care.

The Human Biology Facility includes the Human Sample Management Team and the Human Models Lab. This role will be embedded within the Human Biology Facility and as such will contribute to the day-to-day running of the relevant labs and work closely with this team, in addition to the MANIFEST platform team.

The Human Sample Management Team (HSMT) is responsible for receiving human-derived samples, processing and logging the samples and carrying out assays.  In addition the HSMT can processed blood samples for PBMCs.  Depending on the study requirements, samples may be stored or prepared for serology assays, some of which are carried out by the team. Any sera, whole bloods or plasma that are leftover, are archived and tracked by the team.

Key Responsibilities

• Receive, track, process, aliquot and assay samples
• Process a wide range of pathology specimens, including human tissue and blood
• Carry out tissue fragmentation preparation with fresh tissue collected as part of clinical trials to generate patient derived tissue fragments (PDTFs)
• Carry out DNA and RNA extraction from blood and tissue samples
• Effectively manage laboratory stock and equipment
• Become proficient in various Laboratory Information Management software  systems required
• Understand and follow SOPs and Risk Assessments and be competent in all areas
• Become familiar and compliant with CL2 practices, HTA, GCP, Clinical Research Delivery and other regulatory requirements as needed

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the ‘Apply’ button above.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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