Research Associate

Contract type: Fixed-term ending no later than 30/6/2027

Location: Firth Court, Sheffield, S10 2TN

Summary:

We are seeking a Research Associate to join our multidisciplinary team studying how the immune system controls infection. Cryptococcal meningitis (CM) is a fungal infection of immunocompromised individuals, responsible for over 100,000 deaths globally each year and 20% of AIDS-related deaths. In this project, we are studying a new way that macrophage immune cells can ingest and kill Cryptococcus. We have discovered that macrophages have sub-micron ridges on their surface which improves their ability to interact and phagocytose Cryptococcus.

Key responsibilities

• Design, develop, and perform experiments to study host-pathogen interactions.
• Apply live imaging techniques to observe host-pathogen interactions in vitro, ex vivo, and in vivo.
• Employ advanced microscopy techniques to capture high-resolution images of immune cell interactions.
• Conduct quantitative image analysis to evaluate experimental data.
• Analyse data and interpret results to contribute to the understanding of immune responses to Cryptococcus.
• Collaborate with fellow researchers and team members to successfully implement research projects.
• Prepare manuscripts, reports, and presentations to communicate findings to the scientific community.
• Mentor and support junior members of the research team.

Required qualifications

• PhD in immunology, microbiology, or a related field (or equivalent experience).
• Proficiency in a variety of cell and molecular biology techniques.
• Experience working with in vivo infection models.
• Advanced microscopy experience, including live imaging.
• Strong analytical skills and the ability to work independently.
• Outstanding communication and teamwork skills.

What we offer

Our team at the University of Sheffield, is committed to encouraging an inclusive and accessible research environment. As a member of our team, you will have access to advanced facilities and resources to support your research. We are dedicated to your professional growth and will provide opportunities for career development and mentorship. You will be part of a passionate team that strives to understand and combat human infections through pioneering research. Your work will contribute to advancing our understanding of immune system interactions and potentially lead to new therapeutic approaches for treating cryptococcal meningitis and other infections.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, colour, national origin, sex, gender, gender expression, sexual orientation, age, marital status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodations.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.

Advert information