Research Assistant

We are seeking a Neuropathology Research Assistant to work on an innovative, large-scale, public-private partnership

About the role

We are seeking a Neuropathology Research Assistant to work on an innovative, large-scale, public-private partnership that will use multiple layers of genomic and state-of-the-art neuropathology data generated on human post-mortem brain tissue for drug target identification and prioritisation.

What you would be doing

The Landmark Project is a public-private partnership funded by Parkinson’s UK in collaboration with a consortium of global Pharma companies. The post offers opportunities to work on an internationally unique, large-scale dataset using cutting edge methods for causal inference and multiomic data integration, as well as opportunities to interact with leading drug development scientists globally.

What we are looking for

• Candidates must hold a good first degree or equivalent – e.g. BSc / BA in biological sciences or other appropriate discipline, or equivalent vocational qualification and / or equivalent experience in laboratory management
• Experience in handling human tissues (fresh, frozen, fixed), preferably tissues of the central nervous system (CNS)
• Experience of sectioning of paraffin embedded tissue blocks, preferably human CNS, and tinctorial and immunohistochemical staining of paraffin sections
• Experience of cryosectioning and tinctorial and immunohistochemical staining of frozen sections
• Knowledge of neuroanatomy
• Knowledge of neuropathology
• The ability to manage a research project including planning of experimental milestones
• Excellent communication skills and the ability to deal with a wide range of people and manage small teams
• Ability to write clearly and succinctly for publication
• Ability to work productively including motivate others to produce a high standard of work
• Ability to organise own work with minimal supervision
• Ability to prioritise own work in response to deadlines

What we can offer you

• The post offers opportunities to work on an internationally unique, large-scale dataset using cutting edge methods for causal inference and multiomic data integration.
• Opportunities to interact with leading drug development scientists globally
• A key focus of the research is drug target discovery for Parkinson’s disease (PD), but the research will support target and biomarker discovery across human brain disease broadly.
• A unique feature of the project is that each brain tissue sample will be linked to quantitative neuropathology, including measures of oligomeric tau and alpha-synuclein levels. We anticipate the generation of scRNA-seq profiles on up to 30 million cells across ~1,000 samples, providing a globally important resource for drug target discovery. The RA will work in a multidisciplinary team consisting of neuropathologists, neurologists, bench scientists, computational biologists and statisticians. The Landmark Project will have an international profile
• The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
• Grow your career: Gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression
• Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).

Further information

This is a 2 year Fixed Term contract based at our Hammersmith Campus.

If you require any further details on the role, please contact:

Mike Johnson – m.johnson@imperial.ac.uk

Advert information