Postdoctoral Scientist

About the role:

The aim of this post is to address the mechanisms governing nutrient-host-microbiome interactions that permit systemic immune responses to cancer in mice and humans.

You will work with in vivo mouse models, gut organoids or samples from cancer patients using spectral flow cytometry, microscopy, single-cell RNA sequencing, proteomics, metabolomics in host cells and commensal species to identify instructive factors of microbiome-dependent cancer immunity.

Several posts available. For the background and details of the projects please refer to the Job Description.

About you:

You will have a PhD in either immunology using mouse models or human tissues (preferentially in mucosal or cancer immunology) OR host-microbiome interactions in mice or human (preferentially gut microbiome).

Who we are:

In the Cancer Immunosurveillance group, we combine genetically modified mouse models, transplantable microbiome and diets to disentangle complex nutrient-host-microbiome interactions that define immunity to cancer. Our vision is to identify microbiome-immune checkpoints that can be predictive of immunotherapy response and targeted to overcome immunotherapy resistance.

The group has recently been awarded an ERC starting Grant and is additionally funded by a Cancer Research UK Institute Award and Royal Society Research Grant.

For a taste of what we do please see: Giampazolias* et al Science 2024, Lim KHJ et al JITC 2022, Giampazolias et al Cell 2021, Giampazolias et al Nature Cell Biology 2017, Giampazolias et al Cell Cycle 2018. *co-corresponding author.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (CRUK MI), an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK, the largest independent cancer research organisation in the world with access to outstanding laboratory and animal facilities including germ-free facilities as well as exceptional core services, including spectral and conventional cytometers, next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry. In spring 2023 the Institute moved into the new Paterson Building, a £150 million flagship purpose-built biomedical research centre directly attached to The Christie NHS Foundation Trust, in South Manchester. We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe and Lydia Becker Institute of Immunology and Inflammation (University of Manchester), one of the largest Immunology centres in the UK. Being at the centre of cancer and immunology research in the UK, CRUK MI with the support of its cutting-edge facilities ensure the success of innovative and impactful research aiming to understand basic biological process and improve clinical outcomes.

How to apply?

Please ensure you detail the names of three referees and ensure you submit your application before the closing date specified.

Please note this vacancy will close for applications at 11:59pm on the closing date specified.

For any informal enquiries about this post, please contact Dr. Evangelos Giampazolias: evangelos.giampazolias@cruk.manchester.ac.uk

Closing date: Sunday 1 December 2024.

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