PhD Studentship: Bacterial Evolution in Gut Microbiomes

Primary Supervisor - Dr Falk Hildebrand 

Bacterial strains in the human gut microbiome can live for decades in association to us. During this time their genomes mutate, we assume that this happens partly to adapt to our own lifestyles.  

In this project, we will investigate such mutations and their evolutionary impact, using metagenomic time series data of dietary interventions, family cohorts and experimental evolution trials in mice, created in the hosting research groups. The project will investigate the evolution and spread of important genes (such as virulence factors, antibiotic resistance etc), and revisit the current bacterial species definitions in light of multiple species cooperating within a community. The project aims at creating the robust basis for modelling evolutionary forces at play in high-performing, natural microecosystems.   

During the PhD, the student will learn about high-resolution metagenomics, advanced sequencing techniques, host-associated bacteria and applying evolutionary theory. Exposure to statistics and programming languages (either R, python, Perl, Rust, C++, or equivalent) is expected, specialized skills will be taught and developed through mentorship and collaborations. During this 4-year DTP programme, a research visit with collaborators in France, visiting international conferences and training courses and a 3-month industrial placement are planned as part of a broad and interdisciplinary education.  

The project will be supervised by Dr Falk Hildebrand, Dr Christopher Quince, and Dr Anthony Duncan and is located at the Earlham/Quadram Institute in the Norwich Research Park, UK. The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities, developing bioinformatic solutions to complex microbial questions. Norwich hosts a vibrant and active research community, large student community and multiple startups. It is a mid-sized historical, medieval city with an active pub and coffee scene, situated at the Norfolk coast. 

For further information and to apply, please visit: https://www.falk.science/. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Funding Details

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2024/5 stipend rate: £19,237), and a Research Training Support Grant of £5,000pa for each year of the studentship. 

Closing Date: 25 November 2024 (at 11.59 pm) 

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