PhD Studentship: Single-cell CSI: Development and application of single-cell DNA profiling in forensic science

Primary Supervisor - Dr Iain Macaulay 

Every nucleated cell has the potential to identify us. We shed cells wherever we go and different types of contact result in the transfer and mixture of different cell types. 

Conventional forensic DNA recovery loses information about the molecule - or cell - the DNA originated from.  This information could be critical in mixed samples and establishing where a DNA molecule came from, when it was transferred, and by whom. This project will combine advances in single-cell isolation, phenotyping, and sequencing with established and novel approaches for human identification from individual cells. Using advanced cell sorting, laser capture microdissection and microfluidic approaches, the student will develop and apply methods for human identification from individual cells.  

The student will apply short-tandem repeat (STR)-based analysis methods and sequencing approaches to single cells. The project will focus on method development with translational potential for the justice system but collaboration with the Nieduszynski group will also explore STR heterogeneity in normal human biology 

We offer a highly collaborative research environment, exceptionally well equipped for single-cell genomics. The project offers experience in highly sought after skills in cell biology, genomics and technology development. The student will be mentored to pursue independent lines of research and gain visibility in the wider research community.  

The project has collaborative links with researchers and practitioners in UK forensic science who will provide guidance on technical developments and their applicability in real-world forensic settings.  

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2024/5 stipend rate: £19,237), and a Research Training Support Grant of £5,000pa for each year of the studentship. 

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