PhD Studentship: Using single-cell transcriptomics to understand plant disease

Primary Supervisor - Professor Wenbo Ma 

With the human population projected to reach 9.7 billion by 2050, the looming challenge of feeding the rapidly growing population is threatened by plant pathogens, which cause significant losses in crop yield each year. While controlling microbial pathogens is essential for sustainable agriculture and global food security, developing durable disease resistance requires a deep understanding of the molecular mechanisms underlying pathogenesis.  

This project will utilize single cell transcriptomics and advanced live cell imaging approaches in combination of classic genetics and molecular biology to understand how the devastating Phytophthora pathogens cause disease in plants. Phytophthora cause numerous destructive diseases including potato late blight that triggered the Great Irish Famine and sudden oak death that has killed millions of forest trees. Worldwide losses due to the potato late blight disease alone are estimated to exceed $5 billion annually. By investigating the intricate interactions between Phytophthora and plant hosts in a single-cell level, this project will reveal fundamental principles of Phytophthora pathogenesis and offer new opportunities to develop disease control strategies. The gained knowledge will contribute to battling Phytophthora diseases and enhancing global food security. 

This project offers broad training on cutting-edge, interdisciplinary technologies as well as transferable skills to enhance career planning and professional development so the student will be equipped with the necessary skills to pursue a successful career in science. Excellent support both intellectually and technically will be offered by experienced mentors and support teams. The student will be immersed in a highly collaborative research environment at TSL, NRP and UEA with a strong commitment that supports equality, diversity and inclusion, and promotes open science and excellence in science. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.  

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2024/5 stipend rate: £19,237), and a Research Training Support Grant of £5,000pa for each year of the studentship. 

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