Research Fellow in Regulatory Genomics and Cellular Therapy

The UCL Cancer Institute (https://www.ucl.ac.uk/cancer/) is the hub for cancer research at University College London, one of the World's leading universities. The Institute draws together over 400 talented scientists who are working together to translate research discoveries into developing kinder, more effective therapies for cancer patients.

A position has become available for a post-doctoral research fellow to work between the UCL CAR-T programme under Prof Claire Roddie and the Regulatory Genomics lab, headed by Prof Richard Jenner. A major focus of the UCL CAR Translation group at the UCL Cancer Institute is manipulation of T-cells for therapeutic applications. The purpose of this position is to investigate biological features associated with efficacy, toxicity and persistence of CART in systemic and brain cancers to inform improved CAR designs towards better CAR products.

The Regulatory Genomics laboratory uses genomics, bioinformatics, molecular and biochemical techniques to identify how transcription factors, chromatin modifiers and RNA binding proteins regulate cell differentiation. Over the last 15 years, we have identified mechanisms through which T cell differentiation is controlled. The lab currently comprises the principal investigator, three postdoctoral research associates, and four PhD stude nts. Further details of our research interests can be found at: https://www.ucl.ac.uk/cancer/research/department-cancer-biology/regulatory-genomics-research-group

About the role

The role involves conducting experiments and performing data analysis using the following technologies to investigate CAR therapies used in clinical trials:

• Integration site analysis
• scRNAseq analysis
• Mass spectrometry analysis
• CyToF analysis
• Sc Secretome analysis

The post is funded for 34 months in the first instance.

Your application should include a CV and a Cover Letter: In the Cover Letter please evidence the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the 'Why you have applied for this role' field in the application form, which is limited in the number of characters it will allow.)

About you

The successful candidate must have a PhD (or be in the process of submitting a PhD) in Immunology or or Molecular biology or a related subject and BSc or equivalent in Immunology or Molecular biology or a related subject.

Knowledge of regulation of T cell activation and differentiation and authorship of papers in relevant research areas, either published or under review are desirable but not essential.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B £38,357- £41,005 (salary per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

https://www.ucl.ac.uk/equality-diversity-inclusion/

Advert information