Senior Laboratory Research Scientist - Adrover Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary

We are seeking a Senior Laboratory Research Scientist to join Dr. Adrover’s laboratory, that focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.

The Cancer Macroenvironment Lab is seeking applications for Laboratory Research Scientist candidates to carry out experimental work aimed at understanding the interplay between cancer as a systemic disease and cardiovascular disease. The research in the lab will study how cancer affects the haematopoietic stem cell compartment to induce changes in myeloid populations that can explain the abnormally elevated cardiovascular disease of cancer patients. We will also study how neutrophils (the most abundant immune cell in human circulation) change as a consequence of cancer and cardiovascular disease, as well as during the organism lifespan (both cancer and cardiovascular disease are generally speaking illnesses of the advanced age).

Key Responsibilities

• Provision of technical and research support in the laboratory, including oversight of the mouse colony in close collaboration with other lab members
• Preparation and analysis of samples for flow cytometry and confocal microscopy
• Provision of support with surgical procedures to model cardiovascular disease
• Performance of in vivo intravital microscopy under the direction of senior laboratory staff
• Occasional performance of cell engineering and tissue culture of relevant cancer cells
• Providing technical expertise and input for the development, optimisation and troubleshooting of relevant and novel methodologies
• Independently undertaking own research projects, designing, and executing experiments in consultation with the group leader.
• Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.
• Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring budgets, and routine maintenance of laboratory equipment. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 01/09/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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