Postdoctoral Research Fellow - MRC PPU - UOD1665

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Fellow within the Madsen Group, to lead on a systems biology project that seeks to develop and characterise a novel iPSC-based model system for quantitative studies of phenotypic plasticity in the context of genetic PI3K activation. This is a fixed-term appointment for 2 years, with opportunity for extension for another 2 years. The post is funded by a UKRI Future Leaders Fellowship to Dr Madsen.

The successful applicant will play a leading role in the development and characterisation of a novel induced pluripotent stem cell (iPSC)-based disease model system, iPIK3CA-CC. Co-designed with collaborator Joshua Breunig (Cedars-Sinai Medical Center), this system will enable high-precision, quantitative control of genetic PI3K pathway activation and studies of lineage-specific phenotypic plasticity.

This is a rare and exciting opportunity for an ambitious, bold and creative postdoctoral researcher who will benefit from the acquisition of highly competitive, interdisciplinary skills. These include iPSC culture, state-of-the-art gene engineering, molecular lineage tracing, quantitative single-cell phenotyping (scATACseq, scRNAseq, CyTOF, high content imaging), as well as multi-omic data processing and integration.

Your priorities will include:

• Genetic engineering of iPSCs using the MADR system (PMID: 37283517) and MemorySeq barcodes (PMID: 32735851)
• Multi-omic single-cell phenotyping and data processing
• Preparation of high-quality publications
• Internal and external oral presentations
• Rigorous experimental design

Who we’re looking for:

• You are a systems thinker with an interest in quantitative biology
• You are unafraid of tackling interdisciplinary challenges as part of a team
• You are committed to research integrity and open knowledge sharing
• You plan and prioritise own work to meet deadlines
• You use initiative to develop and lead research projects

We are one of the UK’s leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Dr. Ralitsa Madsen at rmadsen001@dundee.ac.uk or visit ralitsamadsen.wordpress.com/want-to-join-us. To find out more about MRC PPU please visit www.ppu.mrc.ac.uk

As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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