Senior Laboratory Research Scientist - Gene Editing

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Human Biology Facility provides support and expertise to enable research utilising human materials and data, and to develop capability in core areas relating to stem cells, genetic modification and human model systems. We provide support to Crick researchers, including our growing number of clinical scientists, throughout the study lifecycle including sourcing human materials, navigating governance frameworks, evidencing compliance, and providing expert technical services. We facilitate access to tissues, data, and expertise that will underpin our research to benefit human health by fostering interactions between our scientists, support teams and external networks. The Facility is comprised of two core functions, a Governance Team, and Human Models Team.

This SLRS Gene editing role will sit within the Human Biology Facility (HBF) remit, however, will work in collaboration with the existing Gene Modification Service (GeMS) and the Human Embryonic Stem cell Unit (HESCU).

Key Responsibilities

• Lead and coordinate diverse research projects within the HBF
• Play a pivotal role in collaboration with Genetic Modification Service to establish and shape Gene Editing for HBF, including critical infrastructure development, equipment procurement, and laboratory layout design.
• Work collaboratively with the Crick STPs relevant to the running of this service, specifically engaging actively with the Genetic Modification Service on research and design of engineering strategies.
• Work with Head of Lab Operations and the Head of GeMS to expand a new resource for Group leads
• Maintain and develop relevant expertise in CRISPR and gene editing used by the science through consultation, literature review and attending scientific meetings.
• Provide internal and external training in gene editing.
• Focus on extensive editing work with PSCs, including knockouts, single-base variants, and conditional loss-of-function alleles.
• Offer stem cell gene editing training and project consultation services. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 23/08/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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