Postdoctoral Research Scientist - Dr Zoi Diamantopoulou

Project Title: The role of the circadian rhythm on metastasis

Contract term: Fixed up to 6 years, subject to successful review at Year 3

About us

The CRUK Scotland Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.

Project outline

We are seeking a Postdoctoral Research Scientist with a strong passion for unravelling the complexities of metastasis to work on an ambitious project funded by a prestigious UKRI Future Leaders Fellowship. The project aims to investigate the intricate relationship between metastasis and circadian rhythm. Our research builds upon our recent publication, which demonstrates that breast cancer cells spread during sleep (https://www.nature.com/articles/s41586-022-04875-y).

The scientist engaged on this project will analyse samples from a range of cancer mouse models available at the CRUK Scotland Institute and cancer patients to uncover the mechanisms through which the circadian rhythm regulates the metastatic spread of Circulating Tumour Cells (CTCs) and identify molecular vulnerabilities. Furthermore, this will involve employing a combination of cutting-edge microfluidics and robotic technologies, along with single-cell analysis methods, next generation sequencing, genetic engineering, CRISPR screens and imaging techniques.

To be considered for these positions you will have successfully (or nearly) completed a PhD in a relevant field. Expertise in working with mouse models is essential. While prior research experience with CTCs or circadian rhythm would be advantageous, it is not essential, as appropriate training will be provided. Finally, you should demonstrate the ability to conduct both independent and collaborative research, as well as effectively plan and prioritise tasks to ensure the project timelines are met.

For informal enquiries, please email zoi.diamantopoulou@glasgow.ac.uk

Postdoc support

Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:

• Exciting, innovative cancer research projects in state-of-the art labs
• A highly collaborative and interactive research environment
• Access to and training in key advanced technologies, for example imaging and in vivo modelling
• A mentor enabling scheme to aid personal and professional development
• A rich programme of scientific exchange through seminars, workshops and meetings
• Support to make fellowship and small grant applications, including during their transition to their next position
• Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry.

Employee Benefits

• Competitive salary
• 40.5 days annual leave including bank holidays (pro-rata)
• Defined Contribution pension scheme
• Life Insurance scheme
• Employee Assistance Programme
• Season ticket loan
• Additional maternity pay at 6 month’s full pay (subject to service)
• Shared parental leave
• Cycle to work scheme that could save you 26-40% on a bike and accessories.
• Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more.
• On-site secure parking

All applications must be made through our website (via the ‘Apply’ button above).

Interviews will take place between the 5^th and 11^th of September.

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