Research Associate (Protein Engineering)

We are looking for a researcher with a background in protein design and engineering to join the Dafydd Jones group in the Molecular Bioscience division of Cardiff University’s School of Biosciences.

This BBSRC funded project aims to address one of the missing pieces in the cell interactome: protein self-association. Protein-protein interactions (PPIs) play a major role in biology, with their dysregulation contributing to many disease states. Fluorescent proteins have proved pivotal to investigating PPIs in the cell but the underlying fluorescent methods are currently limited to monitoring interactions between two different proteins; self-association of the same proteins cannot be easily measured.

Building on recent work in the Jones lab, your project will generate new fluorescent protein variants optimised for use in the cell to functionally respond when fused to a self-associating protein target.

Your main role will be to conduct research within the area of protein design and engineering, recombinant protein production, protein molecular analysis and cell imaging with a specific focus on fluorescent proteins.

You will have:

• postgraduate degree at PhD level (or nearing completion / submission) in protein biochemistry/protein engineering or relevant industrial experience.
• established expertise and proven portfolio of research and/or relevant industrial experience within the following areas:
  • Computational analysis of protein molecular structure including design aspects (e.g. Rosetta, molecular dynamics).
  • Protein engineering and associated molecular techniques (mutagenesis, cloning, molecular analysis of proteins, recombinant protein production).
  • Spectroscopic analysis of proteins (e.g. absorbance and fluorescence spectroscopy).

The full job description, including application details can be found via the above ‘Apply’ button.

Please contact Dafydd Jones (jonesdd@cardiff.ac.uk) for more information or visit his website at https://profiles.cardiff.ac.uk/staff/jonesdd

This is a full-time position, for a fixed period of 16 months, 35 hours.

Salary: £39,347 - £44,263 per annum (Grade 6)  

Closing date: 26 July 2024

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds. We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

Applications may be submitted in Welsh, and an application submitted in Welsh will not be treated less favourably than an application submitted in English.

Cardiff University is a signatory to the San Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions we will evaluate applicants on the quality of their research, not publication metrics or the identity of the journal in which the research is published. More information is available at: Responsible research assessment - Research - Cardiff University

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