Qualification Type: | PhD |
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Location: | Birmingham |
Funding for: | UK Students |
Funding amount: | Not Specified |
Hours: | Full Time |
Placed On: | 7th June 2024 |
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Closes: | 7th September 2024 |
In the early development of new active pharmaceutical ingredients (APIs), pharmaceutical scientists often have access to only small amounts of material for testing. Even as we move through the development and commercialisation process, the reduction in the amount of API used for experimental purposes will significantly reduce a project’s carbon footprint. As such, the ability better characterise, and thus predict the behaviour of, new APIs can not only help accelerate the development of new products, but also reduce waste and thus improve the sustainability of this development. This project will utilise Discrete Element Modelling (DEM) simulation to comprehensively understand how fundamental particle properties define APIs’ bulk behaviours. The successful applicant will conduct virtual tests on particles with diverse fundamental properties, exploring e.g. packing, compressibility, permeability, cohesion, coordination number, and shear strength. Based on the DEM simulations, AI models will be implemented to allow the prediction of these mesoscale properties.
The AI model's predictions will serve two primary purposes:
Funding notes:
To be eligible for EPSRC funding candidates must have at least a 2(1) in an Engineering or Scientific discipline or a 2(2) plus MSc. To apply please email your cv to cdt-formulation@contacts.bham.ac.uk. Currently, we are only able to accept UK nationals. For details on the Engineering Doctorate scheme visit the homepage: https://www.birmingham.ac.uk/schools/chemical-engineering/postgraduate/eng-d
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